Welcome to Laboratory of Physics of Living Matter
Bienvenue au laboratoire de physique de la matière vivante - LPMV |
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The Laboratory of Physics of Living Matter (LPMV) is part of Institute of Physics of Biological Systems the Faculty of Basic Sciences (FSB) of the Swiss Federal Institute of Technology (EPFL).
The Laboratory is situated at the forth floor in the BSP/Cubotron (Bâtiment des sciences physiques UNIL) , west of the Dorigny campus of Lac Leman Border (site map) |
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| Overview |
The research activity of the laboratory of physics of living matter is mainly devoted to the study of DNA topology, cellular machines, protein mechanics and high-resolution low temperature Atomic Force Microscopy (AFM). Through internal and external collaborations, a certain number of other research activities are carried out in particular on knots hydrodynamics, DNA gel electrophoresis, cell elasticity, cell motility, etc.
The DNA topology activity is mainly centered on the statistical physics of linear and knotted DNA and the scaling exponents for linear DNA were recently determined by AFM.
Concerning the protein mechanics we have developed a new method to determine the spring constant of a single protein by AFM. Cellular machines, like chaperonin, are studied at the single molecule level with the aim of understanding their detailed function.
High resolution AFM at low temperature (liquid nitrogen temperature) is under development in our laboratory. This technique relies on the fact that polymers (such as proteins or DNA) becomes stiff as the temperature is lowered, thus we expect anincrease in resolution for the AFM. |
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| News - Events |
IPSB - LPMV - SOUTENANCE PUBLIQUE DE THESE - 5.11.2010
Dr. Guillaume Witz has successfully presented his public defense
on Friday the 5th of November at 17h00 in Auditoire I - BSP/Cubotron
DNA Topology : A Biophysical Study of DNA Rings, Knots, and Catenanes by Means of Atomic Force Microscopy and Numerical Simulations.
Thèse EPFL, no 4866 (2010). Dir.: Giovanni Dietler.
Congratulations
Visit Webalbum of 5 November |
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| Seminars |
Le Laboratoire de Physique de la Matière Vivante vous invite au séminaire donné par le
Dr. Pierre Parot
le mardi 16 novembre à 11h00 à l'auditoire 3 du BSP (2ème étage)
"Multiple ligand-receptor bonds studied by dynamic force spectroscopy" |
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Le Laboratoire de Physique de la Matière Vivante vous invite au séminaire donné par le
Dr. Marcel Egli
le vendredi 12 novembre à 10h00 à la salle BSP 318
"Biomedical research in space : influence of microgravity on muscle cells" |
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Broadcast form the Radio Suisse Romande about the shape of proteins
Protéines, en forme -19.05.2010.mp3
Les protéines, lorsqu’elles se rapprochent, peuvent former un ruban. C’est le cas des protéines de lait et aussi de certaines protéines responsables de la maladie d’Alzheimer.
Reportage avec le prof. Giovanni Dietler, biophysicien au Laboratoire de physique de la matière vivante de l’EPFL.
Quant à Gisou Van der Goot, professeur au Global Health Institute de l’EPFL, elle explique la manière dont les protéines s’agrègent et se replient, et comment cette science nouvelle est importante pour comprendre certaines maladies.
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News EPFL - The assembly of protein strands into fibrils - 12 avril 2010
The Atomic Force Microscope depicts on its screen the few nanometer thick and few micrometer long fibers as white flexible sticks, crisscrossing the surface on which they are deposited. The very peculiar property of these proteins lies in fact that they can self assemble into complex ribbon-like twisted fibers.
Researchers at ETH Zürich, EPF Lausanne and University of Fribourg have teamed up to take Atomic Force Microscopy images of the fibers and to analyze them using concepts from polymer physics and theoretical modeling. This combination of expertise has lead them to propose a set of general rules governing the assembly of filaments into thicker and twisted ribbon like fibers. Their results are published in the current issue of the scientific journal ”Nature Nanotechnology“. “The model that we propose is extremely precise in its predictions“, says Raffaele Mezzenga, Professor of Food and Soft Materials Sciences at the ETH Zürich. “Up to now there was no such exact and general model for the formation of Amyloid fibers”, continues Giovanni Dietler, Professor of Physics of Living Matter, at the EPF Lausanne next...
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FSB people: Promotions et nominations de Professeurs
Les professeurs Paolo De Los Rios (ITP-LBS) et Vincenzo Savona (ITP-GR-SA) viennent d'être promus Professeur Associé lors de la dernière réunion du Conseil des EPF.
ERC had also awarded Prof. Suliana Manley with an "European Research Council 2009 Starting Grant" for Life Sciences.
Project Title: Protein assembly: From the molecular scale to the mesoscale with super-resolution imaging
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| Publications |
Understanding amyloid aggregation by statistical analysis of atomic force microscopy images
Jozef Adamcik, Jin-Mi Jung, Jérôme Flakowski, Paolo De Los Rios, Giovanni Dietler & Raffaele Mezzenga
Nature Nanotechnology, 2010 |
Microcontroller-driven fluid-injection system for atomic force microscopy
Kasas, S. ; Alonso, L. ; Jacquet, P. ; Adamcik, J. et al.
In: Review of Scientific Instruments, vol. 81, num. 1, 2010, p. 013704
American Institute of Physics, 2010.
ISSN: 0034-6748 |
Near-field scanning optical microscopy using polymethylmethacrylate optical fiber probes
Chibani, H. ; Dukenbayev, K. ; Mensi, M. ; Sekatskii, S. K. et al.
In: Ultramicroscopy, vol. 110, num. 3, 2010, p. 211-215
Elsevier, 2010.
ISSN: 0304-3991
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Scanning Near-field Optical Microscopy-based Study of Local Dynamics of Receptor-Ligand Interactions at the Single Molecule Level
Mensi, Mounir ; Dukenbayev, Kanat ; Sekatski, Serguei ; Dietler, Giovanni
In: Laser Physics, vol. 20, num. 1, 2010, p. 78-84
Date: 2010 |
Temperature-Controlled Assembly of High Ordered/Disordered Dodecylamine Layers on HOPG: Consequences for DNA Patterning
Adamcik, Jozef ; Tobenas, Susana ; Di Santo, Giovanni ; Klinov, Dmitry et al.
In: LANGMUIR, vol. 25, 2009, p. 3159-3162
Date: 2009
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Stiffness Tomography by Atomic Force Microscopy
Roduit, Charles ; Sekatski, Serguei ; Dietler, Giovanni ; Catsicas, Stefan et al.
In: BIOPHYSICAL JOURNAL, vol. 97, 2009, p. 674-677
Date: 2009
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Persistence length and scaling properties of single-stranded DNA adsorbed on modified graphite
Rechendorff, Kristian ; Witz, Guillaume ; Adamcik, Jozef ; Dietler, Giovanni In: The Journal of Chemical Physics, vol. 131, 2009, p. 095103
Date: 2009
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Intracellular nanomanipulation by a photonic-force microscope with real-time acquisition of a 3D stiffness matrix
Bertseva, E. ; Singh, A. S. G. ; Lekki, J. ; Thevenaz, P. et al.
In: NANOTECHNOLOGY, vol. 20, 2009, p. 285709 (9pp)
Institute of Physics, 2009.
ISSN: 0957-4484
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Registration of long-range surface plasmon resonance by angle-scanning feedback and its implementation for optical hydrogen sensing
Konopsky, VN ; Basmanov, DV ; Alieva, EV ; Dolgy, DI ; Olshansky, ED ; Sekatskii, S ; Dietler, G
NEW JOURNAL OF PHYSICS Volume: 11 Article Number: 063049 Published: JUN 30 2009
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Head
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Prof.
Giovanni Dietler
giovanni.dietler[@]epfl.ch |
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| Office |
BSP/Cubotron 409 |
| Phone |
+41 (0)21 6930446 |
| Fax |
+41 (0)21 6930422 |
Publications
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| Secretary |
Ms.
Christine Vuichoud
Christine.Vuichoud[@]epfl.ch |
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| Office |
BSP/Cubotron 410 |
| Phone |
+41 (0)21 6930443 |
| Fax |
+41 (0)21 6930422 |
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Postal
Adress
EPFL SB IPSB
BSP/CUBOTRON (Bât. sciences physiques UNIL)
CH-1015 Lausanne |
| Staff |
Serguei Sekatski
Fabrizio Benedetti
Kanat Dukenbayev
Dimitry Basmanov |
BSP 408
30445 |
Sandor Kasas
Charles Roduit
Livan Alonso
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BSP 411
30458 |
Jae Sun Jeong
Mounir Mensi |
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Guillaume Witz
Masahiro Fujikawa |
BSP 414
34521 |
Andrzej Kulik
Caroline Maillard
Carine Ben Adiba |
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Dusan Vobornik
Andrea Cerreta |
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Naoshi Hotta
Olivier Thorrens |
BSP 424
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| Laurent Braun |
BSP 523
34520 |
| Michel Kessous |
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Jean-Luc
Baumberger |
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| Malgorzata Lekka |
BSP 425
30547 |
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Laboratories
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| Chemical Lab |
BSP 228
30424 |
| AFM/Nanoscope |
BSP 226
30429 |
| SNOM |
BSP 225
30423 |
| CryoAFM |
BSP 224
30428 |
BiosCope
and SNOM |
BSP 221
30450 |
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